By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the enormous physique of uncomplicated technology and medical information linked to adenomatous polyps of the colon, a lot of it encouraged by way of the belief that the majority colorectal carcinomas appear to come up in such polyps. This e-book strives to judge those facts, with specific emphasis on their implications for administration of polyp-bearing matters. themes comprehensively explored contain anatomy and histology of the traditional colon; pathologic features of adenomatous polyps, differential prognosis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic facts for the malignant power of adenomatous polyps; and detection and administration, with unique awareness to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Extra resources for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
Does one crypt exhibiting the higher grade justify placing the entire polyp in that category, or are several clusters of such crypts or a minimum percentage required? J. , 1988). Perhaps of even greater importance is the occasional inability to grade the changes at all. Frequently, the grades merge imperceptibly with one another, and it may be difficult to identify with certainty the highest grade present. , mild variation in nuclear size and mild nuclear stratification) may be confused with reactive changes in mildly dysplastic surface epithelium as described and illustrated above.
These changes in well-differentiated lesions are the reverse of the usual reduced activity of those enzymes found in most carcinomas in which the low levels are believed to result from depressed respiration and increased glycolysis. , 1982), suggesting that changes in glycolysis or pentose metabolism may precede development of frank carcinoma. , 1985). , 1984). Mucin histochemistry studies of both adult and childhood adenomas show a progressive decrease in the amount of mucin with increasing dysplasia.
Cancer 21 : 165-177. Day D, Morson B (1978) The pathology of adenomas. In B Morson (ed): The Pathogenesis of Colorectal Cancer. WB Saunders, Philadelphia, pp 43-57. Deasy JM, SteeleG, Ross DS, Lahey SJ, WilsonRE, MadaraJ (1983) Gut-associated lymphoid tissue and dimethylhydrazine-induced colorectal carcinoma in the Wistar/Furth rat. J Surg Oncol 24:36-40. de Bruin PA, Griffioen G, Verspaget HW, Verheijen JH, Lamers CB (1987) Plasminogen activators and tumor development in the human colon: Activity levels in normal mucosa, adenomatous polyps, and adenocarcinomas.