By Nightingale C.H., et al. (eds.)
Taking readers from the study laboratory to the bedside, this moment version compiles crucial info at the pharmacodynamics of all significant sessions of the antimicrobial armamentarium together with penicillins, cephalosposorins, cephamycins, carbapenems, monobactams, aminoglycosides, quinolones, macrolides, antifungals, antivirals, and rising brokers at the moment in improvement. Written via skilled execs within the box, this consultant makes use of an abundance of examples to depict the way to observe pharmacodynamic ideas to daily scientific perform.
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Additional info for Antimicrobial pharmacodynamics in theory and clinical practice
Complicated skin and skin structure infections Bacteremia Immunocompetent mousethigh; Streptococcus pneumoniae Immunocompetent mousethigh; S. pneumoniae fAUC0–24:MIC ratio: 34 Quinolones Communityacquired respiratory tract infections Animal infection model; organism studied Neutropenic mouse-thigh; gram-negative bacilli Clinically derived PK–PD target fAUC0–24:MIC ratio: 62–75 Quinolones Drug Hospital-acquired pneumonia Disease state TABLE 5 PK–PD Targets Derived from Animal Infection Models and Clinical Data Applying Pharmacodynamics for Susceptibility Breakpoint Selection 37 38 Mouton et al.
Abbreviations: MIC, minimum inhibitory concentration; T>MIC, duration of time the drug concentration remains above the MIC value. Source: Modified from Ref. 66. 34 Mouton et al. 5 1 2 MIC mg/L 4 FIGURE 6 Probabilities of target attainment for levofloxacin orally for 500 mg q24h. The horizontal line indicates the PK/PD target for Streptococcus pneumoniae. 5 L/hr; CV, 14%; Fu, 70%; Ka, 1 hr–1; F, 1. Abbreviations: AUC, area under the concentration–time curve at 24 hours; MIC, minimum inhibitory concentration; PD, phar8 macodynamic; PK, pharmacokinetic.
Mouton JW, van Klingeren B, de Neeling AJ, Degener JE, Commissie Richtlijnen Gevoeligheidsbepalingen. Het vaststellen van gevoeligheidskriteria voor antibacteriele middelen in Nederland: verleden, heden en toekomst. Nederlands Tijdschrift voor Med Microbiol 2000; 8(3):73–78. Swedish Reference Group of Antibiotics. Antimicrobial susceptibility testing in Sweden. Scandinav J Infect Dis 1997; 105S:5–31. Bergan T, Bruun JN, Digranes A, Lingaas E, Melby KK, Sander J. Susceptibility testing of bacteria and fungi.