By Nightingale C.H., et al. (eds.)
Taking readers from the study laboratory to the bedside, this moment version compiles crucial info at the pharmacodynamics of all significant sessions of the antimicrobial armamentarium together with penicillins, cephalosposorins, cephamycins, carbapenems, monobactams, aminoglycosides, quinolones, macrolides, antifungals, antivirals, and rising brokers at the moment in improvement. Written via skilled execs within the box, this consultant makes use of an abundance of examples to depict the way to observe pharmacodynamic ideas to daily scientific perform.
Read Online or Download Antimicrobial pharmacodynamics in theory and clinical practice PDF
Similar theory books
Water Waves: The Mathematical Theory with Applications (Wiley Classics Library)
Deals an built-in account of the mathematical speculation of wave movement in beverages with a unfastened floor, subjected to gravitational and different forces. makes use of either strength and linear wave equation theories, including functions corresponding to the Laplace and Fourier remodel equipment, conformal mapping and complicated variable recommendations more often than not or crucial equations, tools using a Green's functionality.
This monograph presents a concise advent to the most effects and techniques of the fastened element thought in modular functionality areas. Modular functionality areas are traditional generalizations of either functionality and series editions of many vital areas like Lebesgue, Orlicz, Musielak-Orlicz, Lorentz, Orlicz-Lorentz, Calderon-Lozanovskii areas, and others.
- Theory of the Inhomogeneous Electron Gas
- Theory of Fully Ionized Plasmas
- Microeconomía intermedia: Un enfoque actual
- Theory of the Ion-Channel Laser
- Intellectual Property Theory and Practice: A Critical Examination of China’s TRIPS Compliance and Beyond
- Belief Functions: Theory and Applications: 4th International Conference, BELIEF 2016, Prague, Czech Republic, September 21-23, 2016, Proceedings
Additional info for Antimicrobial pharmacodynamics in theory and clinical practice
Example text
Complicated skin and skin structure infections Bacteremia Immunocompetent mousethigh; Streptococcus pneumoniae Immunocompetent mousethigh; S. pneumoniae fAUC0–24:MIC ratio: 34 Quinolones Communityacquired respiratory tract infections Animal infection model; organism studied Neutropenic mouse-thigh; gram-negative bacilli Clinically derived PK–PD target fAUC0–24:MIC ratio: 62–75 Quinolones Drug Hospital-acquired pneumonia Disease state TABLE 5 PK–PD Targets Derived from Animal Infection Models and Clinical Data Applying Pharmacodynamics for Susceptibility Breakpoint Selection 37 38 Mouton et al.
Abbreviations: MIC, minimum inhibitory concentration; T>MIC, duration of time the drug concentration remains above the MIC value. Source: Modified from Ref. 66. 34 Mouton et al. 5 1 2 MIC mg/L 4 FIGURE 6 Probabilities of target attainment for levofloxacin orally for 500 mg q24h. The horizontal line indicates the PK/PD target for Streptococcus pneumoniae. 5 L/hr; CV, 14%; Fu, 70%; Ka, 1 hr–1; F, 1. Abbreviations: AUC, area under the concentration–time curve at 24 hours; MIC, minimum inhibitory concentration; PD, phar8 macodynamic; PK, pharmacokinetic.
Mouton JW, van Klingeren B, de Neeling AJ, Degener JE, Commissie Richtlijnen Gevoeligheidsbepalingen. Het vaststellen van gevoeligheidskriteria voor antibacteriele middelen in Nederland: verleden, heden en toekomst. Nederlands Tijdschrift voor Med Microbiol 2000; 8(3):73–78. Swedish Reference Group of Antibiotics. Antimicrobial susceptibility testing in Sweden. Scandinav J Infect Dis 1997; 105S:5–31. Bergan T, Bruun JN, Digranes A, Lingaas E, Melby KK, Sander J. Susceptibility testing of bacteria and fungi.