Applications of Toxicogenomic Technologies to Predictive by National Research Council, Division on Earth and Life

By National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology

The hot box of toxicogenomics provides a possibly strong set of instruments to raised comprehend the well-being results of exposures to toxicants within the surroundings. on the request of the nationwide Institute of Environmental overall healthiness Sciences, the nationwide examine Council assembled a committee to spot some great benefits of toxicogenomics, the demanding situations to attaining them, and capability ways to overcoming such demanding situations. The record concludes that knowing the opportunity of toxicogenomics to enhance public overall healthiness judgements would require a concerted attempt to generate information, utilize present information, and examine facts in new ways--an attempt requiring investment, interagency coordination, and knowledge administration ideas.

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This database is needed to compile and analyze the information at a more complex level than the current “one disease is caused by one gene” approach. Curation, storage, and mining of these data will require developing and distributing specialized bioinformatic and computational tools. Current public databases are inadequate to manage the types or volumes of data to be generated by large-scale applications of toxicogenomic technologies and to facilitate the mining and interpretation of the data, which are just as important as their generation and storage.

Additional technical challenges include the individual variation in response to an environmental exposure and the persistence of a toxicogenomic signature after exposure. Toxicogenomic technologies should be adapted and applied for the study of exposure assessment by developing signatures of exposure to individual chemicals and perhaps to chemical mixtures. To facilitate the development of exposure-assessment tools based on toxicogenomics, large human population studies should include a collection of samples that can be used for transcriptomic, proteomic, metabolomic, or other toxicogenomic analyses in addition to traditional epidemiologic measures of exposure.

Most of these gene-specific methods work consistently at various genomic locations (that is, they have minimal bias by genomic location) and will be useful for high-resolution analysis of the epigenetic modifications to the genome in toxicogenomic studies. TRANSCRIPTOMIC TECHNOLOGIES Transcriptomics describes the global measurement of mRNA transcripts in a biologic system. This collection of mRNA transcripts represents the transcription of all genes at a point in time. Technologies that allow the simultaneous analysis of thousands of transcripts have made it possible to analyze transcriptomes.

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