Case Studies in Nanotoxicology and Particle Toxicology by Antonietta M Gatti, Stefano Montanari

By Antonietta M Gatti, Stefano Montanari

Case reports in Nanotoxicology and Particle Toxicology provides a highly-illustrated research of the main popular circumstances at the antagonistic results of nanoparticles and their impression on people and the surroundings.

This complete reference demonstrates the potential hazards imposed by means of dealing with and dealing with nanoparticles, exhibiting the consequences of involuntary inhalation or ingestion in the course of their use and after their incineration.

Through using a number of examples, readers will become aware of the prospective dangers and results of operating with nanoparticles, in addition to top practices to avoid those results. The textual content is a necessary reference for an individual operating within the threat evaluate of nanoparticles, together with nanosafety execs, occupational toxicologists, regulatory toxicologists, and clinicians.

  • Presents real-life instances exhibiting the aptitude hazards to human wellbeing and fitness following publicity to nanoparticles
  • An perfect reference for somebody operating within the probability overview of nanoparticles, together with nanosafety pros, occupational toxicologists, regulatory toxicologists, and clinicians
  • Provides examples to aid examine hazards of dealing with engineered nanomaterials
  • Advises at the top varieties of safety and the most secure nanotechnological products

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Extra info for Case Studies in Nanotoxicology and Particle Toxicology

Sample text

18). Then the presence of a noble metal as PM was something unheard of in that district of the organism. The toxicity of silver has been known since ancient times because of argyria, a condition due to chronic ingestion or inhalation of silver dust or compounds of that metal. The most visible symptom is the bluish color of the skin in more or less extended regions of the body, the mucous membranes or the conjunctiva. The deposit of silver particles is irreversible and explains the color. , and many international organizations are wondering if these particles, used because of their antibacterial activity, can have adverse side effects on human health.

We discovered this because the technician who prepared our samples also included a case of a malformed fetus. That was the first case of spina bifida, the developmental congenital disorder caused by the incomplete closing of the embryonic neural tube, where we identified PM. The presence of those particles demonstrated that the placental barrier was not efficient enough to stop the submicronic and nanosized particles, which could reach the fetus, and which lead us to suspect that they could negatively influence its development.

The term “right” needs an explanation. More than once we verified that the sampling of the biological tissue is crucial. In many cases of primary cancer the identification of the interface between the pathological and the healthy tissue is crucial for the analysis. In fact, there is a high probability that these foreign bodies will be found not in the middle of the cancer but at its interface. That is an area where the accumulation of the debris is particularly considerable and their density decreases as one moves away from the interface.

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