By Paul E. Perry (auth.), Frederick J. de Serres, Alexander Hollaender (eds.)
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Extra resources for Chemical Mutagens: Principles and Methods for Their Detection Volume 6
For example, CP is metabolized to an SCE-inducing metabolite far more effectively by S-9 prepared from liver of rats "induced" with Aroclor 1254 or phenobarbital than with 3-methylcholanthrene. , the SCE-inducing ability of AAAf and Nhydroxyacetylaminof1uorene is reduced in the presence of S-9 Mix. (90) Thus, any compound under investigation must be tested both with and without S-9 Mix and serum. The number of SCEs induced by direct-acting, stable chemicals such as MMC increases with the duration of exposure, but the effective length of treatment with unstable or indirect-acting chemicals is difficult to assess.
F. ), Academic Press, New York (1979) (in press). 81. B. A. Kihlman, Sister chromatid exchanges in Vicia/aba. II. Effects of thiotepa, caffeine and 8-ethoxy-caffeine on the frequency of SCE's, Chromosoma 51, 11-18 (1975). 82. A. R. Lehmann and S. Kirk-Bell, Effects of caffeine and theophylline on DNA synthesis in unirradiated and LTV-irradiated mammalian cells, Mutat. Res. 26, 73-82 (1974). 83. J. E. Cleaver, Repair replication and sister chromatid exchanges as indicators of excisable and nonexcisable damage in human (xeroderma pigmentosum) cells, J.
15,61 Treatment of plants with thio-TEPA 1811 and of Chinese hamster cells with a variety of chemicals 165 I leads to chromosomal aberrations, and this damage is potentiated by posttreatment with caffeine, which is said to inhibit postreplication repair. 182 I SCEs, however, are not affected by this treatment, indicating that caffeine-sensitive repair processes are not involved in their formation. Also, the XP variant cells, which are defective in post replication repair, show the same baseline and UV-induced SCE frequency as normal cells.