Chemical Probes in Biology: Science at the Interface of by Jason P. Eiserich (auth.), Manfred P. Schneider (eds.)

By Jason P. Eiserich (auth.), Manfred P. Schneider (eds.)

This NATO complex learn Institute (co-sponsored via FEBS and INTAS) lower than the identify "Chemical Probes in Biology" was once designed to summarize and disseminate fresh professional wisdom relating to a deeper knowing ofbiological phenomena on a molecular point. Such clinical actions -frequently termed Bio-organic Chemistry or Chemical Biology ­ are constituting a hugely interdisciplinary department of chemistry past the normal ways that chemists and biologists were operating some time past. hence, in this get together we have been bringing jointly senior specialists from the disciplines of Chemistry and Biology for you to amalgamate their various but essentially universal pursuits during this quarter. final objective used to be - subsequent to an alternate of knowledge among the 2 medical cultures - the verbal exchange ofexciting chances in interdisciplinary study to the younger scientists current. The assembly was once held within the Anargyros and Korgialenios tuition at the Island ofSpeteses, Greece from 18-30 August 2002. The ASI was once attended via a complete of ninety one students from 23 diversified international locations. a bunch of 27 audio system awarded a sequence of 34 hugely stimulating, informative and academic lectures protecting a large diversity of subject matters proper to the overall topic ofthis assembly: technology on the InteifaceofChemistry, Biology and medication. The lectures have been complemented by way of a complete of 89 posters provided by means of the younger students and a chain of brief lectures derived thereof This was once basically one ofthe highlites of the assembly making a vigorous surroundings of interplay and highbrow creativity - general phenomena for the complete meeting.

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81 2Mana1 6 Mana1 r 4GlcNAcP1 4GlcNAc,81 2/ . / ManP1 4GlcNAcP1 4 GlcNAc,8 17 1 H,N Val-Iie-Ala-Phe-Asn-Glu-Leu-LysCOOH Scheme 6. 1 equiv glycosyl asparagine, TBTU, DIPEA, DMF; b) i 20% piperidine, DMF; ii 3 equiv Fmoc-AA-Pfp, DhbtOH, DMF; c) TFA/H,O (95:5); d) NaOMe, MeOH, pH 9, 35% overall yield. The use of preformed glycosyl asparagines usually is a reliable means of N-glycopeptide synthesis. Rapid and convergent access is provided by methods that utilize on-resin coupling of glycosylamines to aspartic acid containing peptides.

1995) J. Bioi. Chem. 270, 2748927494. BIOLOGICAL ACTIVITIES OF THE PHOSPHOINOSITIDE DERIVATIVES, THE GLYCEROPHOSPHOINOSITOLS STEFANIA MARIGGIO', BEATRICE MARIA FILIPPI, CRISTIANO IURISCI AND DANIELA CORDA Department ofCell Biology and Oncology Istituto di Ricerche Farmacologiche "Mario Negri" Consorzio Mario Negri Sud Via Nazionale 66030 Santa Maria Imbaro, Chieti, Italy E-mail: corda@negrisud it 1. Abstract The phosphoinositides and the inositol-containing compounds in general are essential components of cell machineries involved in virtually all cell functions.

Chem. 270, 2748927494. BIOLOGICAL ACTIVITIES OF THE PHOSPHOINOSITIDE DERIVATIVES, THE GLYCEROPHOSPHOINOSITOLS STEFANIA MARIGGIO', BEATRICE MARIA FILIPPI, CRISTIANO IURISCI AND DANIELA CORDA Department ofCell Biology and Oncology Istituto di Ricerche Farmacologiche "Mario Negri" Consorzio Mario Negri Sud Via Nazionale 66030 Santa Maria Imbaro, Chieti, Italy E-mail: corda@negrisud it 1. Abstract The phosphoinositides and the inositol-containing compounds in general are essential components of cell machineries involved in virtually all cell functions.

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