Diet-Microbe Interactions in the Gut: Effects on Human by Kieran Tuohy, Daniele Del Rio

By Kieran Tuohy, Daniele Del Rio

Drawing on specialist critiques from the fields of food, intestine microbiology, mammalian body structure, and immunology, Diet-Microbe Interactions for Human Health investigates the proof for a unified disorder mechanism operating throughout the intestine and its resident microbiota, and linking many inflammation-related persistent nutrition linked ailments. state-of-the-art post-genomic experiences can spotlight the $64000 position performed via our resident intestinal microbiota in identifying human well-being and ailment. Many continual human illnesses linked to smooth existence and diets - together with these localized to the intestinal tract like inflammatory bowel ailment and celiac illness, and extra pervasive systemic stipulations corresponding to weight problems, diabetes and heart problems - are characterised through aberrant profiles of intestine micro organism or their metabolites. lots of those ailments have an inflammatory foundation, frequently offering with a prolonged low-grade systemic irritation, hinting at chronic and irrelevant activation of inflammatory pathways. throughout the presentation and research of contemporary meals experiences, this booklet discusses the potential mechanisms underpinning the disorder approaches linked to those pathologies, with excessive fats diets showing to predispose to ailment, and biologically lively plant parts, generally fiber and polyphenols, showing to minimize the danger of continual illness development.

  • One complete, translational resource for all features of food and diet's impression on gastrointestinal overall healthiness and disease
  • Experts in food, vitamin, microbiology and immunology take readers from the bench examine (cellular and biochemical mechanisms of supplementations and food) to new preventive and healing approaches
  • Clear displays via major researchers of the mobile mechanisms underlying nutrition, immune reaction, and gastrointestinal illness aid training nutritionists and clinicians (gastroenterologists, endocrinologists) map out new components for scientific examine and structuring scientific recommendations

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Extra resources for Diet-Microbe Interactions in the Gut: Effects on Human Health and Disease

Example text

The co-occurrence of microbial species in similar abundance could be seen as an indication of their being part of an integrated network, providing a set of mutually complementary functions integrated in a multi-organismal pathway. DIET-MICROBE INTERACTIONS IN THE GUT THE GUT MICROBIOTA IN HUMAN EVOLUTION 19 The size of this super-network can be estimated integrating the HMP and the MetaHIT studies, indicating that gene content in gut microbiota is at least 150-fold higher than the human genome.

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145. Silvi S, Rumney CJ, Cresci A, Rowland IR. Resistant starch modifies gut microflora and microbial metabolism in human flora-associated rats inoculated with faeces from Italian and UK donors. J Appl Microbiol. 1999;86:521À530. 146. Bowey E, Adlercreutz H, Rowland I. Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. Food Chem Toxicol. 2003;41(5):631À636. 147. Tuohy K, Davies M, Rumsby P, Rumney C, Adams MR, Rowland IR. Monitoring transfer of recombinant and nonrecombinant plasmids between Lactococcus lactis strains and members of the human gastrointestinal microbiota in vivo—impact of donor cell number and diet.

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